Integrated Love Wave Device Dedicated to Biomolecular Interactions Measurements in Aqueous Media
نویسندگان
چکیده
Mass-sensitive electro-acoustic devices such as surface acoustic wave (SAW)micro-balances, capable to operate with aqueous media are particularly favorable for thedevelopment of biosensors. Their dimensions and physical properties offer a large potentialin biological fluid investigations, especially for measuring physical phenomenon (massdeposition, adsorption, pressure...). In this work, we propose a specific gratingconfiguration to lower the influence of viscosity of fluids which reduces the signal dynamicsof the surface wave transducers. A dedicated liquid cell also has been developed to isolatethe electro-active part of the device. The fabrication of the cell is achieved using theSU-8TMphoto-resist, allowing for manufacturing thick structures preventing any contact between thetested liquids and the transducers. Furthermore, the sensing area has been optimized tooptimize the sensor gravimetric sensitivity. The operation of the sensor is illustrated bydetecting bovine serum albumin (BSA) adsorption in the sensing area.
منابع مشابه
Generation of Love Wave in a Media with Temperature Dependent Properties Over a Heterogeneous Substratum
The present paper deals with the generation of Love waves in a layer of finite thickness over an initially stressed heterogeneous semi-infinite media. The rigidity and density of the layer are functions of temperature, i.e. they are temperature dependent. The lower substratum is an initially stressed medium and its rigidity and density vary linearly with the depth. The frequency relation of Lo...
متن کاملInfluence of the Imperfect Interface on Love-Type Mechanical Wave in a FGPM Layer
In this study, we consider the propagation of the Love-type wave in piezoelectric gradient covering layer on an elastic half-space having an imperfect interface between them. Dispersion relation has been obtained in the form of determinant for both electrically open and short cases. The effects of different material gradient coefficients of functionally graded piezoelectric material (FGPM) and ...
متن کاملIntegrated Optic Surface Plasmon Resonance Measurements in a Borosilicate Glass Substrate
The surface plasmon resonance (SPR) technique is a well-known optical method that can be used to measure the refractive index of organic nano-layers adsorbed on a thin metal film. Although there are many configurations for measuring biomolecular interactions, SPR-based techniques play a central role in many current biosensing experiments, since they are the most suited for sensitive and quantit...
متن کاملDynamics of Love-Type Waves in Orthotropic Layer Under the Influence of Heterogeneity and Corrugation
The present problem deals with the propagation of Love-type surface waves in a bedded structure comprises of an inhomogeneous orthotropic layer and an elastic half-space. The upper boundary and the interface between two media are considered to be corrugated. An analytical method (separation of variables) is adapted to solve the second order PDEs, which governs the equations of motion. Equations...
متن کاملInfluences of Heterogeneities and Initial Stresses on the Propagation of Love-Type Waves in a Transversely Isotropic Layer Over an Inhomogeneous Half-Space
In the present paper, we are contemplating the influences of heterogeneities and pre-stresses on the propagation of Love-type waves in an initially stressed heterogeneous transversely isotropic layer of finite thickness lying over an inhomogeneous half space. The material constants and pre-stress have been taken as space dependent and arbitrary functions of depth in the respective media. To sim...
متن کامل